منابع مشابه
For a PDK1 inhibitor, the substrate matters.
More than 20 protein kinases are directly activated by 3-phosphoinositide-dependent kinase 1 (PDK1), which is a central component of the pathways that regulate cell growth, proliferation and survival. Despite the importance of PDK1 in cell signalling, highly selective PDK1 inhibitors have not been described. In this issue of the Biochemical Journal, Dario Alessi's group and their collaborators ...
متن کاملThe substrate matters in the Raman spectroscopy analysis of cells
Raman spectroscopy is a powerful analytical method that allows deposited and/or immobilized cells to be evaluated without complex sample preparation or labeling. However, a main limitation of Raman spectroscopy in cell analysis is the extremely weak Raman intensity that results in low signal to noise ratios. Therefore, it is important to seize any opportunity that increases the intensity of the...
متن کاملThe Digital Synaptic Neural Substrate: Size and Quality Matters
We investigate the ‘Digital Synaptic Neural Substrate’ (DSNS) computational creativity approach further with respect to the size and quality of images that can be used to seed the process. In previous work we demonstrated how combining photographs of people and sequences taken from chess games between weak players can be used to generate chess problems or puzzles of higher aesthetic quality, on...
متن کاملPhilosophy matters in brain matters
PURPOSE Although most neuroscientists and physicians would argue against Cartesian dualism, Descartes's version of the psyche/soma divide, which has been controversial since he proposed it in the seventeenth century, continues to haunt contemporary neurological diagnoses through terms such as functional, organic, and psychogenic. Drawing on my own experiences as a person with medically unexplai...
متن کاملMatters of sex: sex matters.
Despite the popular concept that heart disease preferentially affects the male population, in every year for the past 16 years, cardiovascular disease has killed more women than men.1 Unfortunately, a disparity still exists between men and women in the diagnosis and aggressive treatment of heart disease. The perception that women are relatively protected is reflected by the fact that women are ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.160937